Brent Burns, Colin White and Logan Couture scored for the Sharks, who again struggled to find answers against St. Louis, losing for the sixth time in seven meetings this season.
Jussi Jokinen scored on a deflection with 8:05 left to lift the Carolina Hurricanes past the San Jose Sharks, 3-2 on Friday night.
Joe Pavelski had two goals and two assists against a goalie playing in the NHL for the first time in nearly a year, leading the Sharks past the Capitals 5-3 Monday night.
Benn Ferriero scored the tiebreaking goal with 14:20 remaining in the third period to send the San Jose Sharks off on a lengthy trip on a winning note, beating the Chicago Blackhawks 5-3 on Friday night.
Michal Handzus and Brent Burns scored in the shootout and the San Jose Sharks rallied to a 2-1 victory over the Calgary Flames on Tuesday night.
Logan Couture scored two of San Jose’s team-record five goals in the first 14:47 as the Sharks beat the Tamba Bay Lightning 7-2 Wednesday night.
Brent Burns, Joe Pavelski and Logan Couture scored in a 4:29 span of the third period to help the San Jose Sharks overcome a two-goal deficit and beat the Colorado Avalanche 5-4 Thursday night.
Marc-Edouard Vlasic and Brent Burns scored for San Jose, which has lost three straight since a season-opening win.
The San Jose Sharks acquired the topflight defenseman they had been seeking, sending a package headlined by forward Devin Setoguchi to the Minnesota Wild for All-Star Brent Burns.