The Boston Red Sox had not lost in the World Series since Game Seven of the 1986 World Series, after sweeping in both 2004 and 2007.
The Red Sox beat the Rays 7-4 in Game 2 of the ALDS, and will have a chance to clinch the series Monday night in Tampa.
The NL West champion D-backs added a front-line starter Friday and boosted their bullpen, acquiring pitchers Trevor Cahill, Craig Breslow and cash from the Oakland Athletics.
The Athletics were seeking their fourth consecutive win, all coming on the road. But they instead dropped to 6-11 in their last 17 games in Toronto, dating to 2009.
Conor Jackson had a two-run home run in the first inning when the A’s hit for the cycle with four consecutive batters, but Oakland’s bullpen imploded and wasted a solid outing by starter Rich Harden.
Jack Hannahan and Lou Marson had RBI singles in the 12th inning, lifting the Cleveland Indians to a 4-3 victory over the Oakland Athletics on Thursday.
Left-handed reliever Craig Breslow and the Oakland Athletics have agreed to a $1.4 million, one-year contract, avoiding arbitration.