FRESNO, Calif. (CBS SF & AP) — Three people have been hospitalized after a Greyhound bus and a big rig crashed on Interstate 5 near Kettleman City in the Central Valley.

The California Highway Patrol says the crash occurred around 4:40 a.m. Thursday on northbound Interstate 5 at Highway 41. The bus ended up on an embankment and a semi-truck flipped.

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The bus was traveling to San Francisco and was carrying 46 passengers plus a driver. Two injured passengers and the driver of the truck were taken to Coalinga Regional Hospital. Their conditions were not immediately known.

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Investigators told CBS 47 that fog did not appear to have played a role in the crash.

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CHP closed northbound lanes on I-5 and diverted traffic around the crash.