SAN FRANCISCO (KCBS) – A Sonoma County couple is about to make the biggest donation in University of California, San Francisco history.

Former Citigroup CEO Sandy Weill and his wife Joan are planning to donate $185 million for a new neuroscience institute at UCSF.

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University officials say not only is this the largest donation the school has ever received, it’s among the largest ever for brain research in the United States.

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Construction is set to begin next year on a $316 million building to house the Weill Institute for Neurosciences.

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The Weill’s hope the institute will help improve the lives of people with Alzheimer’s, autism and other brain ailments.