San Francisco 49ers Headlines

Wentz Leads Colts to Rain-Soaked 30-18 Win Over 49ersCarson Wentz threw two TD passes and ran for another score to lead the Indianapolis Colts to a rain-soaked 30-18 victory over the San Francisco 49ers on Sunday night.
Jimmy Garoppolo Named Starter For 49ers Vs. Colts, Trent Williams Could Be OutJimmy Garoppolo made it through the week of practice completely healthy and will start at quarterback Sunday for San Francisco but the 49ers could be missing left tackle Trent Williams.
49ers Head Into Bye Week After Trey Lance Sprains Knee In 1st Career StartRookie Trey Lance's first career start for the San Francisco 49ers featured a bad interception, a couple of promising moments and a knee injury that could sideline him for a week or two.
49ers Fall to Cardinals in 1st NFL Start for Trey LanceThe Arizona Cardinals rode a stellar defensive performance to a 17-10 win over the San Francisco 49ers on Sunday.
49ers Place George Kittle on Injured Reserve With Calf InjuryThe San Francisco 49ers placed star tight end George Kittle on injured reserve Saturday with a calf injury that has been bothering him for weeks.
Injured Jimmy Garoppolo Out For Sunday; Rookie Trey Lance Gets 1st Start Vs. CardinalsRookie quarterback Trey Lance will make his first start for the San Francisco 49ers after Jimmy Garoppolo was ruled out of this week's game with a calf injury.
49ers' Deebo Samuel Becoming a Complete ReceiverNow in his third season with the 49ers, Deebo Samuel is leading the NFL in yards receiving through four weeks.
San Francisco 49ers Still Not Ready To Rule Jimmy Garoppolo Out For SundaySan Francisco 49ers coach Kyle Shanahan was still holding onto hope Wednesday that injured quarterback Jimmy Garoppolo can recover enough to be able to play Sunday against the NFC West leading Phoenix Cardinals.
Garoppolo Hurt; Lance, 49ers Fall to Seahawks 28-21The Seattle Seahawks rebounded from back-to-back losses by beating the San Francisco 49ers 28-21 on Sunday.